Reducing neuronal nitric oxide synthase (nNOS) expression in the ventromedial hypothalamus (VMH) increases body weight and blood glucose levels while decreasing physical activity in female mice.
Pamela R. Hirschberg, Dashiel M. Siegel, Suraj Benerji Teegala, Munir Rahbe, Pallabi Sarkar, Vanessa H. Routh
The paper reduces nNOS in VMH of female mice and observes increased body weight, blood glucose, and reduced activity, contradicting the hypothesis about orexin neuron inhibition.
bioRxiv · May 15, 2024 · PreprintNeuroscience