ImmunologybioRxivPreprint
Reprogramming BCMA-Targeted CAR-T Cells through γ-Secretase Modulation Blocks Antigen Shedding and Extends CAR-T Longevity
Sheetal Sharma Sheetal, Varnit Chauhan, Zahoor Ahmad Bhat…·Tanveer Ahmad
This paper develops SHEDLOCK CAR-T cells that block BCMA shedding, enhancing their cytotoxicity and longevity in multiple myeloma models.
2 citations