Helices on interdomain interface couple catalysis in the ATPPase domain with allostery in Plasmodium falciparum GMP synthetase
S. Shivakumaraswamy, N. Pandey, L. Ballut, S. Violot, N. Aghajari, H. Balaram
This study identifies helices at the interdomain interface of Plasmodium falciparum GMP synthetase that couple ATPPase catalysis with GATase activation through domain crosstalk.
bioRxiv · Feb 11, 2020Biochemistry