2D or 3D? How in vitro cell motility is conserved across dimensions, and predicts in vivo invasion
S. Galarza, H. Kim, N. Atay, S. Peyton, J. M. Munson
The paper compares 2D and 3D in vitro cell motility models to assess their predictive power for in vivo cell invasion, finding positive correlations between 2D metrics and 3D migration, and a negative correlation between 3D invasion and glioblastoma in vivo.
bioRxiv · May 5, 2019 · PreprintBioengineering