J. M. Munson

Mitigating reactive oxygen species production and increasing gel porosity improves lymphocyte motility and fibroblast spreading in photocrosslinked gelatin-thiol hydrogels

This study shows that reducing reactive oxygen species and increasing hydrogel porosity improves cell viability and function in photocrosslinked gelatin-thiol hydrogels.

Model discovery approach enables non-invasive measurement of intra-tumoral fluid transport in dynamic MRI

A physics-informed computational method measures fluid dynamics in tumors, showing differences in fluid velocity between breast and brain cancer tissues.

Fusobacterium nucleatum induces pancreatic cancer cell proliferation and migration by regulating host autocrine and paracrine signaling

This study shows that Fusobacterium nucleatum in pancreatic cancer promotes cell proliferation and migration through autocrine and paracrine cytokine signaling.

Generation of nonlinear and spatially-organized 3D cultures on a microfluidic chip using photoreactive thiol-ene and methacryloyl hydrogels

This paper develops a microfluidic method to create 3D cell cultures with precise spatial organization using photoreactive hydrogels and demonstrates its effectiveness with human T cells.

2D or 3D? How in vitro cell motility is conserved across dimensions, and predicts in vivo invasion

The paper compares 2D and 3D in vitro cell motility models to assess their predictive power for in vivo cell invasion, finding positive correlations between 2D metrics and 3D migration, and a negative correlation between 3D invasion and glioblastoma in vivo.

Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model

This study shows convective flow increases glioblastoma invasion in mice via CXCR4-CXCL12, and CXCR4 antagonists block this effect.

Applicability of Drug Response Metrics for Cancer Studies using Biomaterials

This paper clarifies inconsistent drug response metrics in cancer biomaterial studies and provides best practices for their reporting.