Interaction between host genes and M. tuberculosis lineage can affect tuberculosis severity: evidence for co-evolution
M. L. McHenry, J. Bartlett, R. P. Igo, E. Wampande, P. Bencheck, H. Mayanja-Kizza, K. Fluegge, N. B. Hall, S. Gagneux, S. Tishkoff, C. Wejse, G. Sirugo, W. H. Boom, M. Joloba, S. M. Williams, C. Stein
The paper investigates the interaction between host genetic variants and Mycobacterium tuberculosis lineage to determine their combined effect on TB severity, finding significant interactions that support host-pathogen co-evolution.
bioRxiv · Sep 14, 2019Evolutionary Biology