3D soft hydrogels induce human mesenchymal stem cells "deep" quiescence
D. Boaventura Gomes, A. F. Henriques Lourenco, C. Tomasina, B. Chompff, H. Liu, N. Bouvy, S. Camarero-Espinosa, L. Moroni
This paper shows that 3D alginate hydrogels induce a deep quiescent state in hMSCs, characterized by cell cycle arrest and upregulated quiescence markers, unlike 2D cultures.
bioRxiv · Mar 11, 2021 · PreprintBioengineering