Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study
M. Marchante, F. Barrachina, E. Mestres, M. Acacio, K. S. Potts, S. Piechota, B. Paulsen, A. D. Noblett, A. B. Figueroa, N. Costa-Borges, C. C. Kramme
This study shows that using human stem cell-derived ovarian support cells for in vitro maturation in mice leads to healthy live births without reprotoxic effects across generations.
bioRxiv · Apr 4, 2024 · PreprintPharmacology & Toxicology