Quantifying "just-right" APC inactivation for colorectal cancer initiation
M. Brunet Guasch, N. Feeley, I. Soriano, S. Thorn, I. Tomlinson, M. Nicholson, T. Antal
The paper quantifies the tumorigenic effect of partial APC inactivation in colorectal cancer, finding it confers a 50-fold higher cancer progression risk than complete inactivation.
bioRxiv · Jul 10, 2024 · PreprintCancer Biology