Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of obligate intracellularity.
S. D. M. Arras, N. Sibaeva, R. J. Catchpole, N. Horinouchi, D. Si, A. M. Rickerby, K. Deguchi, M. Hibi, K. Tanaka, M. Takeuchi, J. Ogawa, A. M. Poole
This paper creates an E. coli strain lacking ribonucleotide reduction and shows it adapts to depend on host-derived deoxyribonucleotides, mimicking evolutionary steps in obligate intracellular life.
bioRxiv · Sep 28, 2022Microbiology