Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development
N. Imprachim, Y. Yosaatmadja, J. Newman
This study determines the crystal structures of SARS-CoV-2 NSP14 and identifies fragment inhibitors, providing insights into its enzymatic activities and potential drug targets.
bioRxiv · Mar 11, 2022Biochemistry