A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans
R. Romero-Bueno, A. Fragoso-Luna, C. Ayuso, N. Mellmann, A. Kavsek, C. G. Riedel, J. D. Ward, P. Askjaer
This paper introduces a C. elegans model of progeria by mutating baf-1 to mimic the human NGPS mutation, showing accelerated aging and altered gene expression.
bioRxiv · Mar 17, 2024Cell Biology