BiophysicsbioRxivPreprint
Tracing the substrate translocation mechanism in P-glycoprotein
T. Gewering, D. Waghray, K. Parey…·Q. Zhang
This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.
DOI 10.1101/2022.04.28.489897