Topoisomerase I Essentiality, DnaA-independent Chromosomal Replication, and Transcription-Replication Conflict in Escherichia coli
J. Gowrishankar, J. Krishna Leela, N. Raghunathan
This paper shows that topA is essential for E. coli viability and identifies transcription-replication conflicts and cSDR as causes of lethality in topA mutants.
bioRxiv · Apr 16, 2021Microbiology