Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes
H. Ruan, R. Mandla, N. Ravi, G. Galang, A. W. Soe, J. E. Olgin, D. Lang, V. Vedantham
This study identifies GPCRs in SAN pacemaker cardiomyocytes and shows that CCKAR activation slows their firing rate via reduced phase 4 depolarization.
bioRxiv · Jan 24, 2023 · PreprintPhysiology