Quantifying local malignant adaptation in tissue-specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level
N. Tokutomi, C. Moyret-Lalle, A. PUISIEUX, S. Sugano, P. Martinez
The paper quantifies local malignant adaptation in cancer by analyzing genetic convergence and divergence across 2,742 cancer genomes, revealing environmental adaptation differences between pre-malignant lesions and metastatic clones.
bioRxiv · Sep 4, 2018Cancer Biology