A. Puisieux

Plakins are involved in the maintenance of epithelial polarity

The paper identifies plakins as regulators of epithelial polarity by showing their downregulation in polarity loss and EMT progression, and demonstrates their causal role through experimental knockdown.

Spatial transcriptomics reveal pitfalls and opportunities for the detection of rare high-plasticity breast cancer subtypes

The paper uses spatial transcriptomics to identify specific markers for rare high-plasticity breast cancer subtypes, showing that bulk expression signatures are limited by stromal contamination.

CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

The paper shows CD4 T cells and neutrophils promote EMT in breast cancer by analyzing murine tumor models and human cohorts.

RAS-induced transformation of mammary epithelial cells relies on ZEB1-dependent cellular reprogramming via a paracrine process

This study shows RAS-induced transformation of mammary epithelial cells depends on ZEB1-dependent reprogramming via a paracrine process involving senescent cell-derived cytokines.

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

In vivo characterisation of the toxicological properties of DPhP, one of the main degradation products of aryl phosphate esters.

This study investigates the toxicological effects of DPhP in mice, finding significant biological impacts including altered fatty acid metabolism and weight loss.

Biophysical properties of intermediate states of EMT outperform both epithelial and mesenchymal states.

The paper investigates the biophysical properties of intermediate EMT states and finds they exhibit distinct structural and mechanical features compared to epithelial and mesenchymal states, with implications for tumor-cell dissemination.

Quantifying local malignant adaptation in tissue-specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level

The paper quantifies local malignant adaptation in cancer by analyzing genetic convergence and divergence across 2,742 cancer genomes, revealing environmental adaptation differences between pre-malignant lesions and metastatic clones.