TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes
N. V. Yang, S. Rogers, R. Guerra, D. J. Pagliarini, E. Theusch, R. M. Krauss
This study shows that statin-induced downregulation of TOMM40 and TOMM22 disrupts mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes, and overexpression of these genes rescues these effects.
bioRxiv · Jun 24, 2023 · PreprintCell Biology