Conformational Plasticity of the ClpAP AAA+ Protease Couples Protein Unfolding and Proteolysis
K. E. Lopez, A. N. Rizo, E. Tse, J. Lin, N. W. Scull, A. C. Thwin, A. L. Lucius, J. Shorter, D. R. Southworth
This study determines high-resolution structures of E. coli ClpAP complex in substrate-bound states to elucidate the mechanism of protein unfolding and proteolysis coupling.
bioRxiv · Oct 29, 2019Biophysics