Nabla Bio

De novo design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute

This paper designs hundreds of functional GPCR-targeting antibodies using a scaled generative model, achieving picomolar affinities and agonist activity for CXCR7.

De novo design of epitope-specific antibodies against soluble and multipass membrane proteins with high specificity, developability, and function

This paper introduces JAM, a generative system for de novo antibody design that achieves high-affinity, developable antibodies against various targets without experimental optimization.