Recurrent Escape from Osimertinib-Induced Senescence Promotes Genomic Instability Associated with Therapeutic Resistance
Nazia Jamil, Qualia Hooker, Nadjet Cornejal, H. Dean Hosgood, Hayley M. McDaid
This paper shows that osimertinib resistance in EGFR+ NSCLC arises from recurrent senescence escape leading to genomic instability, suggesting cytotoxic therapies are more effective than targeted approaches.
bioRxiv · Feb 8, 2026 · PreprintCancer Biology