A corticopapillary Gdf15 response links maladaptive collecting duct remodeling to polyuria during lithium exposure
Lucie Zerarga, Marie Himbert, Mélanie Try, Lydie Cheval, Pravina Muthan, Justine Billet, Nicolas Salaun, Clarice S. Groeneveld, Gaëlle Brideau, Sylvie Demaretz, Rémi Toutain, Luciana Morla, Emmanuelle Vidal‐Petiot, Martin Flamant, François Vrtovsnik, , Nahid Tabibzadeh
This study identifies Gdf15 as a key mediator of lithium-induced collecting duct dysfunction and remodeling, linking spatial stress responses to functional and structural kidney injury.
bioRxiv · Oct 19, 2026 · PreprintPharmacology & Toxicology