Cytosolic mannosyltransferases involved in the ER N-glycosylation pathway exhibit bacterial ancestry
Si Xu, Shuai Chen, Yi Gu, Yifan Huang, Nakanishi Hideki, Xiao‐Dong Gao
The paper investigates the evolutionary origins of ALG1 and ALG2 mannosyltransferases, finding that ALG2 likely originated from bacterial ancestors and ALG1 homologs are exclusive to bacterial lineages.
bioRxiv · Oct 15, 2025 · PreprintMolecular Biology