N-Acetylaspartate Synthesis as a Thermodynamic Relief Mechanism for Mitochondrial Aspartate Aminotransferase
Narayanan Puthillathu, John R. Moffett, Barbara Stauch Slusher, Aryan M. A. Namboodiri
The paper models mitochondrial aspartate metabolism to show that NAA synthesis by ASPNAT relieves thermodynamic constraints on AAT under low OAA conditions.
bioRxiv · Sep 9, 2026 · PreprintNeuroscience