Barbara Stauch Slusher

This study uses proteomic analysis in aged rhesus macaques to show that GCPII inhibition alters region-specific protein expression patterns linked to Alzheimer's disease pathology.

The paper models mitochondrial aspartate metabolism to show that NAA synthesis by ASPNAT relieves thermodynamic constraints on AAT under low OAA conditions.

BCG therapy reduces tau pathology and improves cognitive function in PS19 mice by modulating myeloid cell activity and neuroinflammation.

This study shows that inhibiting glutamine metabolism with JHU083 enhances macrophage phagocytosis of Mtb by altering lipid metabolism and inflammatory markers.

This study identifies nuclear GAPDH translocation as a mediator of stress-induced cardiac hypertrophy through BRG1-associated chromatin remodeling in mice and human patients.

This study shows that inhibiting glutamine metabolism with JHU083 reduces tumor progression by altering macrophage polarization in immunocompetent mouse models.

The paper develops pharmacological tools to selectively target central versus peripheral dopamine D2-like receptors and shows their distinct roles in treating dysglycemia.

This study identifies CTPS1 as a vulnerability in MYC-driven medulloblastoma and shows that combining CTPS1 and CHK1 inhibition synergistically reduces tumor growth in vivo.

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

This paper develops a dendrimer-conjugated GCPII inhibitor (D-2PMPA) that improves cognition in MS mice without affecting disease severity.

This study shows that inhibiting nSMase2 improves myelin quality by protecting oligodendrocytes during remyelination.