Immediate transcriptional changes initiated by direct cell-cell contact between cytotoxic T cells and cancer cells
Zhouhui Qi, Madeleine Lehander, Narmadha Subramanian, Eirini Giannakopoulou, Johanna Olweus, Michael Hagemann-Jensen, Christoph Ziegenhain, Petter S. Woll
The paper investigates immediate transcriptional changes in T cells upon direct contact with cancer cells using single-cell transcriptomics and identifies distinct T cell subsets associated with reduced TCR diversity.
bioRxiv · Feb 18, 2026 · PreprintImmunology