CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation during cellular differentiation
Magdalena A. Karpińska, Yi Zhu, Zahra Fakhraei Ghazvini, Shyam Ramasamy, Mariano Barbieri, T. B. Ngoc Cao, Natalie Varahram, Abrar Aljahani, Michael Lidschreiber, Argyris Papantonis, A. Marieke Oudelaar
The paper shows that CTCF depletion disrupts chromatin hub formation but not enhancer-promoter interactions, which still drive gene expression during differentiation.
bioRxiv · Nov 20, 2024 · PreprintGenomics