Functional surrogacy enables Vascular Ehlers-Danlos Syndrome modelling in zebrafish in the absence of a COL3A1 ortholog
Daniel A. Baird, Nataliya Pidlisnyuk, Anna Matischen, Zuzanna Matelowska, Sookyung Seo, Nurhaziqah Supari, Jessica Bowen, Glenda J. Sobey, Meena Balasubramanian
The paper develops a zebrafish model to assess COL3A1 variants of uncertain significance by using functional surrogacy through col5a1 knockout and human COL3A1 mRNA co-injection.
bioRxiv · Jul 12, 2026 · PreprintGenetics