Proteostasis Modelling using Deuterated Water Metabolic Labeling and Data-Independent Acquisition Mass Spectrometry
Henock M. Deberneh, Daniel James Wilkinson, Hannah Crossland, Natan Basisty, Kenneth Smith, Philip James Atherton, Rovshan G. Sadygov
The paper introduces a method combining deuterated water labeling and DIA-MS/MS to quantify protein turnover rates, validated in a murine model.
bioRxiv · Nov 25, 2025 · PreprintBioinformatics