Mixed effects modeling of the synergy between immune checkpoint and thrombin inhibitors in a preclinical mouse model of colon cancer
Nathanael Cox, Indrani Nayak, Zihai Li, Jayajit Das
The paper uses nonlinear mixed-effects modeling to study synergy between immune checkpoint and thrombin inhibitors in a mouse colon cancer model, identifying mechanisms like CD8+ T cell expansion.
bioRxiv · Aug 4, 2026 · PreprintPharmacology & Toxicology