Intrinsically Dominant Conformational Diversity in PDZ1 within the Tandem PDZ1-PDZ2 of Human Syntenin-1 Underlined by Crystal Structures.
Natsuno Ando, Yuya Hanazono, Koya Sakuma, Nobutaka Numoto, Ryusei Hamajima, Takeshi Tenno, Atsunori Oshima, Nobutoshi Ito, Hidekazu Hiroaki
This study reveals that PDZ1 in the Syntenin-1 tandem domain exhibits intrinsic conformational diversity, contrasting with PDZ2's structural conservation, and suggests functional specialization for ligand recognition and domain stabilization.
Protein Science · May 5, 2026Peer-reviewedBiophysics