Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Julia M. Flynn, Neha Samant, Gily S. Nachum, David T. Barkan, Neşe Kurt Yılmaz, Celia A. Schiffer, Stephanie A. Moquin, Dustin Dovala, Daniel N. A. Bolon
The paper performs a comprehensive mutational scan of SARS-CoV-2 Mpro to identify resistance mechanisms and guide inhibitor design.
eLife · Jun 20, 2022Peer-reviewedMolecular Biology