Intravenous anti-abeta immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 mice
Philip Pikus, Gracie S. Healey, Elizabeth Xia, Giorgi Shautidze, Neha Siddapureddy, Yichien Lee, Christopher Albanese, Olga Catalina Rodriguez, R. Scott Turner, George William Rebeck
This study shows that anti-Aβ immunotherapy in APOE4 mice increases cerebral amyloid angiopathy and vascular damage, while APOE3 mice show no significant changes.
bioRxiv · Feb 11, 2026 · PreprintNeuroscience