ANALYSIS OF GLOMERULAR TRANSCRIPTOMES FROM NEPHROTIC PATIENTS SUGGEST APOL1 RISK VARIANTS IMPACT PARIETAL EPITHELIAL CELLS
Agustin Gonzalez‐Vicente, Dana C. Crawford, William S. Bush, Zhenzhen Wu, Leslie A. Bruggeman, Viji Nair, Felix H. Eichinger, Oliver Wessely, Matthias Kretzler, John F. O’Toole, John R. Sedor, Kidney Precision Medicine Project, Nephrotic Syndrome Study Network
The paper analyzes glomerular transcriptomes to show APOL1 risk variants affect parietal epithelial cells in nephrotic patients, linking gene expression patterns to disease outcomes.
medRxiv · Nov 5, 2024 · PreprintGenetic & Genomic Medicine