Oliver Wessely

This study investigates how inflammatory fibroblasts in ulcerative colitis and colitis-associated cancer contribute to disease progression through senescence and epigenetic memory.

This study identifies regional transcriptomic differences in mouse podocytes during injury, revealing distinct gene expression patterns and potential therapeutic targets in focal segmental glomerulosclerosis.

This study uses single-nucleus transcriptomics to analyze age-related changes in mouse kidney regions, revealing region-specific and cell-type-specific aging patterns in podocytes.

This study shows BICC1 interacts with PKD1 and PKD2, exacerbating ADPKD severity through RNA metabolism, using animal models, genetic studies, and human cohorts.

The paper creates a poly(A) isoform-aware single-cell and spatial atlas of the human bladder, identifying fibroblast niches and their spatial relationships.

The paper investigates how alternative polyadenylation (APA) regulates urothelial differentiation using single-cell RNA-seq and spatial imaging, showing APA's role in shaping cell state-specific polyadenylation sites and transcriptome diversity.

The paper analyzes glomerular transcriptomes to show APOL1 risk variants affect parietal epithelial cells in nephrotic patients, linking gene expression patterns to disease outcomes.

The paper maps cell types, architecture, and signaling networks in the human ureter using single-cell and spatial transcriptomics to inform tissue engineering strategies.