Defining the Limits of hPSC Derived Models: hPSC-MSNs Fail to Recapitulate Authentic Striatal Identity
Oliver J.M. Bartley, Ngoc Nga Vinh, Mariah J. Lelos, Nigel M. Williams, Sophie V. Precious, A. E. Rosser
This study shows that hPSC-derived medium spiny neurons (hPSC-MSNs) do not fully replicate the epigenetic and transcriptional features of authentic fetal MSNs, highlighting limitations in their fidelity.
bioRxiv · Jun 25, 2024 · PreprintCell Biology