Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
Sriram Pendyala, Katie Partington, Nicholas Bradley, Abbye E. McEwen, Gwenneth Straub, Hyeon-Jin Kim, Shawn Fayer, Daniel L. Holmes, Katherine A. Sitko, Riddhiman K. Garge, Ziyu R. Wang, Melinda K. Wheelock, Allyssa J. Vandi, Rachel L. Powell, Clayton E. Friedman, , Douglas M. Fowler
The paper introduces VIS-seq, an image-based method to assess variant effects on cellular phenotypes, revealing multidimensional variant impacts across different diseases.
Cell · May 12, 2026Peer-reviewedGenomics