Causal considerations can determine the utility of machine learning assisted GWAS
Sumit Mukherjee, Zachary Ryan McCaw, David Amar, Rounak Dey, Thomas W. Soare, Kaiwen Xu, Hari Somineni, Nicholas Eriksson, Colm T. O’Dushlaine
This study shows that machine learning-derived phenotypes for GWAS can lead to false discoveries depending on their causal relationship with the target phenotype and environment.
bioRxiv · Dec 16, 2024 · PreprintGenetics