David Amar

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

The Long Non-coding RNA Landscape of Endurance Exercise Training

This study identifies tissue-specific lncRNA responses to endurance exercise in rats, revealing sex differences and potential therapeutic implications.

Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

Pitfalls in performing genome-wide association studies on ratio traits

This paper shows that genome-wide association studies on ratio traits can be misleading, as associations may be driven by the denominator rather than the numerator, and proposes a method to correct for collider bias.

Causal considerations can determine the utility of machine learning assisted GWAS

This study shows that machine learning-derived phenotypes for GWAS can lead to false discoveries depending on their causal relationship with the target phenotype and environment.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

EmbedGEM: A framework to evaluate the utility of embeddings for genetic discovery

EmbedGEM evaluates embeddings for genetic discovery by assessing heritability and disease relevance using polygenic risk scores and genome-wide association statistics.

The mitochondrial multi-omic response to exercise training across tissues

This study maps multi-omic mitochondrial changes across 19 tissues in rats after endurance exercise training, identifying tissue-specific adaptations and disease-related hubs.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

Deconvoluting complex correlates of COVID19 severity with local ancestry inference and viral phylodynamics: Results of a multiomic pandemic tracking strategy

The paper integrates multi-omic data to identify genetic and microbiome factors associated with severe COVID-19, independent of ancestry and social factors.

Mono- and bi-allelic protein truncating variants in alpha-actinin 2 cause cardiomyopathy through distinct mechanisms

The paper investigates how mono- and bi-allelic ACTN2 mutations cause cardiomyopathy through distinct mechanisms using patient-derived iPSC-cardiomyocytes and CRISPR-Cas9 editing.

High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs

This paper develops a high-throughput method to generate host and pathogen genomic data from single nasopharyngeal swabs of COVID-19 patients.

Genetics of 38 blood and urine biomarkers in the UK Biobank

UK Biobank genetics of 38 blood and urine lab tests yields 1,857 independent loci; combining biomarker and disease polygenic scores improves FinnGen prediction of incident renal failure and alcoholic cirrhosis.

Constraint-based analysis for causal discovery in population-based biobanks

The paper introduces cGAUGE, a causal inference pipeline for biobanks, detecting 102 causal relationships including new direct links and feedback loops in 70 phenotypes from 337,198 UK Biobank subjects.

An extensive enhancer-promoter map generated by genome-scale analysis of enhancer and gene activity patterns

The paper introduces FOCS, a method to infer enhancer-promoter links using activity patterns, and presents an extensive E-P map covering over 300,000 links.

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

This study identifies 101 genetic loci associated with hand grip strength in 334,925 UK Biobank participants and links grip strength to brain-related gene expression and health outcomes.