Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling
Nicola Fameli, Oluseye A. Ogunbayo, Cornelis van Breemen, A. Mark Evans
The paper characterizes L-SR nanojunctions in PASMCs and shows they are essential for Ca2+ signaling via RyR3, with model simulations demonstrating the threshold for CICR.
bioRxiv · Jan 28, 2014Cell Biology