AI discovery of sequence rules for RNA polymerase II pausing revises the pause-release model of gene activation
Nova Fong, Nicolas Huynh, Benjamin Erickson, Ryan M. Sheridan, Srinivas Ramachandran, Mihaela van der Schaar, David L. Bentley
The paper uses AI to discover sequence rules for RNA polymerase II pausing, challenging the pause-release model of gene activation by showing pausing is not required for certain activation responses.
bioRxiv · Sep 22, 2026 · PreprintMolecular Biology