ComplexDesign: sequence-hallucination design of protein binders bridging multiple proteins
J Q Xu, Milong Ren, Ning Qi, Xinru Zhang, Zaikai He, Chungong Yu, Dongbo Bu
ComplexDesign is a method for designing multichain protein complexes by optimizing sequences to fold proteins and form inter-chain interactions, achieving high success rates in designing dimers, trimers, and tetramers.
bioRxiv · Jun 24, 2026 · PreprintBioinformatics