J Q Xu

ComplexDesign is a method for designing multichain protein complexes by optimizing sequences to fold proteins and form inter-chain interactions, achieving high success rates in designing dimers, trimers, and tetramers.

This study shows that resistance to different WRN inhibitors in MSI-H cancers creates orthogonal vulnerabilities, enabling alternating therapy and mutation-tolerant inhibitor design.

The paper shows Pseudomonas aeruginosa uses a CRISPR-Cas system to silence a proline-codon toxin that stops phage growth, revealing a defense mechanism against anti-CRISPR phages.