Cortical folding patterns are encoded in the geometry of the unfolded neocortex.
Roberto Toro, Katja Heuer, Nisrine Aflak, Vı́ctor Borrell, Clément Caporal, Camino de Juan Romero, Benoît Larrat, Antoine Legouhy, Erik Maikranz, Jean‐François Mangin, Kevin Martinez-Anhom, Sébastien Mériaux, Isabel Reillo, Nicolas Traut
This study shows that neocortical geometry at birth predicts adult cortical folding patterns and sulcal-gyral fate, suggesting geometry provides positional information alongside molecular signals.
bioRxiv · Jun 7, 2026 · PreprintNeuroscience