Synthetic BiologyPhilosophical Transactions of the Royal Society B Biological SciencesPeer-reviewed
Success probability of high-affinity DNA aptamer generation by genetic alphabet expansion
Michiko Kimoto, Hui Pen Tan, Yaw Sing Tan…·Ichiro Hirao
The paper estimates success probabilities for generating high-affinity DNA aptamers with unnatural bases and identifies structural factors that improve binding affinity.
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