Natural selection in the evolution of SARS-CoV-2 in bats, not humans, created a highly capable human pathogen
O. A. MacLean, S. Lytras, S. Weaver, J. B. Singer, M. F. Boni, P. Lemey, S. L. Kosakovsky Pond, D. L. Robertson
The paper shows SARS-CoV-2's ability to infect humans stems from its evolutionary history in bats, not human adaptation, with evidence of positive selection in bat viruses and weak purifying selection in SARS-CoV-2.
bioRxiv · May 28, 2020 · PreprintEvolutionary Biology