First-in-Class Small Molecules Inhibit c-MET Activity Through Self-Regulatory Elements in Its Extracellular Domain
Okan Sezgin, Yeliz Yılmaz, Ezgi Bağırsakçı, Aykut Üren, Neşe Atabey, Serdar Durdağı
This study identifies small molecules that inhibit c-MET activity by targeting its extracellular domain, showing reduced cell viability and autophosphorylation in HCC cells.
bioRxiv · May 5, 2026 · PreprintCancer Biology