Genotype-phenotype map of an RNA-ligand complex
Olga Puchta, Grzegorz J. Sobczyk, Vanessa Smer-Barreto, Hollie Ireland, Marc Vendrell, Diego A. Oyarzún, Janusz Marek Bujnicki, Graeme Whyte, Grzegorz R. Kudla
The paper systematically explores RNA-ligand interactions by analyzing mutations in an RNA aptamer, revealing complex phenotypic effects and training a model to predict RNA structure from epistasis.
bioRxiv · Dec 17, 2020 · PreprintSynthetic Biology