A systemic clock brake: Period1 stabilizes the circadian network under environmental stress
Pureum Kim, Vinod Kumar, Nicholas Garner, Oliver Jayasinghe, Gregg Roman, Shaun B. Walters, Tuan Vo, Quan Hoang Nguyen, Josephine Bowles, Trent M. Woodruff, Warrick John Inder, Jeremy Hunt, Isabel Heyde, Henrik Oster, Oliver Rawashdeh
This study identifies Per1 as a systemic regulator of circadian stability, showing that its loss accelerates clock realignment and protects against jetlag-related disruptions.
bioRxiv · Jun 12, 2025 · PreprintNeuroscience