Restoring the Chondron: Pericellular Matrix Reconstitution Enhances Mechano-Inflammatory Resilience and Modulates Chondrocyte-Neuron Crosstalk
Huan Meng, Junxuan Ma, Jiangyao Xu, Olivier Chassande, Line Kawtharany, Martin James Stoddart, Sibylle Grad, Zhen Li
This study shows that reconstituting a collagen VI-rich pericellular matrix in chondrocytes reduces inflammatory and mechanical stress responses and modulates neuron interactions.
bioRxiv · Sep 11, 2026 · PreprintMolecular Biology